Frontiers of Retrovirology will bring together leading human retrovirus researchers to review current progress and to chart future challenges. Internationally renowned speakers will present their insights into the principles guiding the life cycle of endogenous retroelements, complex human retroviruses, and their pathogenic interactions with the hosts.

Abstract and poster submission is now closed. The scholarships for this conference, kindly provided by ANRS will be announced on the final day of the event, two from the selected talks and two from the selected posters.

The full conference programme is shown below.

17:00 - 18:00	Registration and poster setup
18:20 - 18:30	Welcome Address Bryan Vickery, BioMed Central
18:30 - 20:00	Poster session 1 & Welcome Reception

08:00	Registration
08:30	Opening Address Retroviral Restriction Factors: New Mechanisms of Innate Immunity Stephen Goff, Howard Hughes Medical Institute, Columbia University, New York, USA
09:00	Keynote Address Endogenous retroviruses: from infectious elements to bona fide genes with a physiological role Thierry Heidmann, Institut Gustave-Roussy, Villejuif, France
09:20	Keynote Address Approach and Progress in Attempts to Develop A Preventive Vaccine Against HIV Robert C. Gallo, Institute of Human Virology, University Maryland School of Medicine, Maryland, USA

Session 1: Evolution and the beneficial roles of retroelements
Chairman: Malik Harmit. Fred Hutchinson Research Center, Seattle, USA

09:40	Silencing of retroviruses by small RNAs in Drosophila Alain Bucheton, Institut de Genetique Humaine, Montpellier, France
10:00	Emergence of novel retroviruses Walid Heneine, Centers for Disease Control and Prevention, Atlanta, Georgia, USA
10:20	Host genome influences on susceptibility to HIV- Amalio Telenti , Universite de Lausanne, Lausanne, Switzerland

Special Talk

10:40	Viruses: a vast reservoir of genetic diversity and driver of global processes Curtis Suttle, University of British Columbia, Vancouver, Canada
11:00	Coffee Break

Selected Talks

11:30	Aris Katzourakis: Paleovirology reveals the macroevolution of complex retroviruses
11:40	Irina R. Arkhipova: Reverse transcriptases of retroviruses and retroelements: an evolutionary perspective
11:50	Anne Dupressoir: The Syncitin-A envelope gene of retroviral origin is essential for mouse placental development
12:00	Rachel O’Neil: An ultra-conserved retrovirus produces a new class of small RNA and defines genetic and epigenetic components of the vertebrate centromere
12:10	Severine Chambeyron: Small RNA-mediated control of retrotrotransposons in Drosophila
12:20	Novel and unexpected cellular partners for HIV-1 integrase and Tat Mauro Giacca, International Centre for Genetic Engineering and Biotechnology, Trieste, Italy
12:40	Lunch

Session 2: Restriction of Retroelements
Chairman: Yamina Bennasser, Institut de Genetique Humaine, Montpellier, France

13:40	The fallout from crossing paths with cellular cytidine deaminases Simon Wain-Hobson, Institut Pasteur, Paris, France
14:00	Antagonizing the effects of Bst-2/tetherin: multiple ways to accomplish one single goal? Klaus Strebel, National Institutes of Health, Bethesda, USA
14:20	The Ups and Downs of HIV-1 Gene Expression Rosemary Kiernan, Institut de Genetique Humaine, Montpellier, France
14:40	Evolution of TRIM antiviral genes in primate genomes Harmit Malik, Fred Hutchinson Research Center, Seattle, USA
15:00	Coffee Break

Special Talk

15:30

siRNA expressed from endogenous retroelements Olivier Voinnet, Institut de Biologie Moleculaire des Plantes, Strasbourg, France

Selected talks

15:50	Jeremy Luban: TRIM5alpha contributes to the anti-viral state
16:00	Christine Kozak: Adaptive evolution of the virus resistance gene Apobec in the genus Mus
16:10	Yuntao Wu: Dichotomous effects of the cofilin kinase LIMK1 on the early steps of HIV-1 infection of CD4 T cells
16:20	Masaaki Miyazawa: Mouse APOBEC3 affects the production of virus neutralizing antibodies by restricting early retroviral replication, not by altering B-cell repertoire
16:30	Olivier T. Keppler: HIV-1 antagonism of CD317/tetherin is species-specific and involves Vpu-mediated proteasomal degradation the intrinsic immunity factor.
16:40	Sébastien Legros: HTLV-1 inhibits stress granules formation by interacting with the histone deacetylase 6 (HDAC6)
16:50	Olivier Rohr: The cellular cofactor CTIP2 is a negative p-TEFb regulator contributing to HIV-1 post-integration latency
17:00	Yamina Bennasser: Interplay between HIV-1 replication and RNAi effectors
17:10	Poster Session 2
19:00	End of day 2 – Coaches depart for Chateau de Flaugergues
19:30	Wine tasting and tour of Chateau
20:00	Conference dinner at Chateau de Flaugergues

Session 3: Hijacking the cellular machinery
Chairman: Ali Saib, Institut Universitaire d'Hematologie, Paris, France

08:30	Genomic RNA packaging in lentiviruses Andrew Lever, University of Cambridge, Cambridge, UK
08:50	Dynamic interplay between HIV-1 integrase and host cofactors Stephane Emilian, Institut Cochin, Paris France
09:10	Novel cellular processes that regulate post-transcriptional expression of HIV-1 transcripts Kuan-Teh Jeang, Bethesda, USA
09:30	Immunological and virological aspects of HIV cell-to-cell transfer Olivier Schwartz, Institut Pasteur, Paris, France

Special Talk

09:50	Conserved genes from yeast to human involved in retroelement transposition Suzanne Sandmeyer, University of California, Irvine, USA
10:10	Coffee Break

Selected Talks

10:40	David Harrich: A U5 repressor of reverse transcription is required for optimal HIV-1 infectivity and replication
10:50	Delphine Muriaux: Targeting of MuLV Gag to the plasma membrane is mediated by PI(4,5)P2 and phosphatidylSerine
11:00	Diana Ayinde: The HIV-2 Vpx protein usurps the Cul4A-DDB1-DCAF ubiquitin ligase to overcome a post-entry block in macrophage infection
11:10	Françoise Bex: Post-translational modifications of the Tax oncoprotein of human T-cell leukemia virus control cytoplasmic and nuclear steps in Tax-mediated activation of the NF-kB pathway
11:20	Matthias Geyer: Insights into the activation of transcription elongation by lentiviruses: Structure of the CyclinT1-Tat-TAR RNA complex
11:30	Daniel Arosio: Nuclear trafficking of HIV-1 pre-integration complexes in living cells
11:40	Sébastien Desfarges: Analysis of LEDGF/p75 binding sequences by ChIP-Seq
11:50	Alessandro Marcello: Nuclear organization and the regulation of HIV-1 gene expression
12:00	Howard Gendelman: HIV-1 Hijacks Tunneling Nanotubes and Secretory Microvesicles for Intercellular Spread in Monocyte-Derived Macrophages
12:10	Lunch

Session 4 Pathogenesis
Chairman: Olivier Schwartz, Institut Pasteur, Paris, France

13:10	Biochemical and Virological Analysis of the Preference for the K65R Multi-Resistance Nucleoside Mutation in Subtype C Viruses Mark Wainberg, McGill University, Montreal, Canada
13:20	Post-entry events of efficient R5 vs. inefficient X4 HIV-1 replication in primary CD4+ T lymphocytes, a transcriptome analysis Guido Poli, San Raffaele Scientific Institute, Milan, Italy
13:40	Retroviral envelope and their receptors: on the (nutrient) road again Marc Sitbon, Institut de Genetique Moleculaire de Montpellier, Montpellier, France
14:00	Endogenous Retroelements and Autoimmunity Dan Stetson, University of Washington, Seattle, USA
14:20	Role of Regulatory T cells in the pathogenesis of HIV-1 infection Yves Levy, Groupe Henri-Mondor Albert-Chenevier, Creteil, France
14:40	Coffee Break
15:10	Inflammatory control in AIDS-resistant non human primates Michaela Müller-Trutwin, Institut Pasteur, Paris, France

Selected Talks

15:30	Fabrizio Mammano: Partial inhibition of HIV replication by type-I interferons: impact of cell-to-cell viral transfer
15:40	Prabal Banerjee: HTLV-1 infection of humanized SCID mice recapitulates Adult T-cell Leukemia/Lymphoma (ATLL) development
15:50	Mickaël J. Ploquin: High avidity virus-specific CD4+ T cells are lost during retroviral infection upon cognate interaction with B cells
16:00	Pierre Roques: Tissue viral dynamics in SIV infected macaques with highly active antiviral therapy (HAART)
16:10	Julien Guergnon: What do we learn from genome wide association study performed on HIV-1 infected Long Term Non Progressors individuals?

Closing Conference

16:20	Novel vaccine and gene therapy approaches against HIV-AIDS Ben Berkhout, University of Amsterdam, Amsterdam, Netherlands
16:40	Closing Address Monsef Benkirane, Institut de Genetique Humaine, Montpellier, France
17:00	End of day 3

Monday 21 September
Tuesday 22 September
Wednesday 23 September