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  • Introduction

    Frontiers of Retrovirology will bring together leading human retrovirus researchers to review current progress and to chart future challenges. Internationally renowned speakers will present their insights into the principles guiding the life cycle of endogenous retroelements, complex human retroviruses, and their pathogenic interactions with the hosts.

    Abstract and poster submission is now closed. The scholarships for this conference, kindly provided by ANRS will be announced on the final day of the event, two from the selected talks and two from the selected posters.

    The full conference programme is shown below.

  • Monday 21 September

    17:00 - 18:00 Registration and poster setup
    18:20 - 18:30 Welcome Address
    Bryan Vickery, BioMed Central
    18:30 - 20:00 Poster session 1 & Welcome Reception
  • Tuesday 22 September

    08:00Registration
    08:30Opening Address
    Retroviral Restriction Factors: New Mechanisms of Innate Immunity
    Stephen Goff, Howard Hughes Medical Institute, Columbia University, New York, USA
    09:00Keynote Address
    Endogenous retroviruses: from infectious elements to bona fide genes with a physiological role
    Thierry Heidmann, Institut Gustave-Roussy, Villejuif, France
    09:20Keynote Address
    Approach and Progress in Attempts to Develop A Preventive Vaccine Against HIV
    Robert C. Gallo, Institute of Human Virology, University Maryland School of Medicine, Maryland, USA

    Session 1: Evolution and the beneficial roles of retroelements
    Chairman: Malik Harmit. Fred Hutchinson Research Center, Seattle, USA

    09:40Silencing of retroviruses by small RNAs in Drosophila
    Alain Bucheton, Institut de Genetique Humaine, Montpellier, France
    10:00Emergence of novel retroviruses
    Walid Heneine, Centers for Disease Control and Prevention, Atlanta, Georgia, USA
    10:20Host genome influences on susceptibility to HIV-
    Amalio Telenti , Universite de Lausanne, Lausanne, Switzerland

    Special Talk

    10:40Viruses: a vast reservoir of genetic diversity and driver of global processes
    Curtis Suttle, University of British Columbia, Vancouver, Canada
    11:00Coffee Break

    Selected Talks

    11:30Aris Katzourakis: Paleovirology reveals the macroevolution of complex retroviruses
    11:40Irina R. Arkhipova: Reverse transcriptases of retroviruses and retroelements: an evolutionary perspective
    11:50Anne Dupressoir: The Syncitin-A envelope gene of retroviral origin is essential for mouse placental development
    12:00Rachel O’Neil: An ultra-conserved retrovirus produces a new class of small RNA and defines genetic and epigenetic components of the vertebrate centromere
    12:10Severine Chambeyron: Small RNA-mediated control of retrotrotransposons in Drosophila
    12:20Novel and unexpected cellular partners for HIV-1 integrase and Tat
    Mauro Giacca, International Centre for Genetic Engineering and Biotechnology,
    Trieste, Italy
    12:40Lunch

    Session 2: Restriction of Retroelements
    Chairman: Yamina Bennasser, Institut de Genetique Humaine, Montpellier, France

    13:40The fallout from crossing paths with cellular cytidine deaminases
    Simon Wain-Hobson, Institut Pasteur, Paris, France
    14:00Antagonizing the effects of Bst-2/tetherin: multiple ways to accomplish one single goal?
    Klaus Strebel, National Institutes of Health, Bethesda, USA
    14:20The Ups and Downs of HIV-1 Gene Expression
    Rosemary Kiernan, Institut de Genetique Humaine, Montpellier, France
    14:40Evolution of TRIM antiviral genes in primate genomes
    Harmit Malik, Fred Hutchinson Research Center, Seattle, USA
    15:00Coffee Break

    Special Talk

    15:30siRNA expressed from endogenous retroelements
    Olivier Voinnet, Institut de Biologie Moleculaire des Plantes, Strasbourg, France

    Selected talks

    15:50Jeremy Luban: TRIM5alpha contributes to the anti-viral state
    16:00Christine Kozak: Adaptive evolution of the virus resistance gene Apobec in the genus Mus
    16:10Yuntao Wu: Dichotomous effects of the cofilin kinase LIMK1 on the early steps of HIV-1 infection of CD4 T cells
    16:20Masaaki Miyazawa: Mouse APOBEC3 affects the production of virus neutralizing antibodies by restricting early retroviral replication, not by altering B-cell repertoire
    16:30Olivier T. Keppler: HIV-1 antagonism of CD317/tetherin is species-specific and involves Vpu-mediated proteasomal degradation the intrinsic immunity factor.
    16:40Sébastien Legros: HTLV-1 inhibits stress granules formation by interacting with the histone deacetylase 6 (HDAC6)
    16:50Olivier Rohr: The cellular cofactor CTIP2 is a negative p-TEFb regulator contributing to HIV-1 post-integration latency
    17:00Yamina Bennasser: Interplay between HIV-1 replication and RNAi effectors
    17:10Poster Session 2
    19:00End of day 2 – Coaches depart for Chateau de Flaugergues
    19:30Wine tasting and tour of Chateau
    20:00Conference dinner at Chateau de Flaugergues
  • Wednesday 23 September

    Session 3: Hijacking the cellular machinery
    Chairman: Ali Saib, Institut Universitaire d'Hematologie, Paris, France

    08:30Genomic RNA packaging in lentiviruses
    Andrew Lever, University of Cambridge, Cambridge, UK
    08:50Dynamic interplay between HIV-1 integrase and host cofactors
    Stephane Emilian, Institut Cochin, Paris France
    09:10Novel cellular processes that regulate post-transcriptional expression of HIV-1 transcripts
    Kuan-Teh Jeang, Bethesda, USA
    09:30Immunological and virological aspects of HIV cell-to-cell transfer
    Olivier Schwartz, Institut Pasteur, Paris, France

    Special Talk

    09:50Conserved genes from yeast to human involved in retroelement transposition
    Suzanne Sandmeyer, University of California, Irvine, USA
    10:10Coffee Break

    Selected Talks

    10:40David Harrich: A U5 repressor of reverse transcription is required for optimal HIV-1 infectivity and replication
    10:50Delphine Muriaux: Targeting of MuLV Gag to the plasma membrane is mediated by PI(4,5)P2 and phosphatidylSerine
    11:00Diana Ayinde: The HIV-2 Vpx protein usurps the Cul4A-DDB1-DCAF ubiquitin ligase to overcome a post-entry block in macrophage infection
    11:10Françoise Bex: Post-translational modifications of the Tax oncoprotein of human T-cell leukemia virus control cytoplasmic and nuclear steps in Tax-mediated activation of the NF-kB pathway
    11:20Matthias Geyer: Insights into the activation of transcription elongation by lentiviruses: Structure of the CyclinT1-Tat-TAR RNA complex
    11:30Daniel Arosio: Nuclear trafficking of HIV-1 pre-integration complexes in living cells
    11:40Sébastien Desfarges: Analysis of LEDGF/p75 binding sequences by ChIP-Seq
    11:50Alessandro Marcello: Nuclear organization and the regulation of HIV-1 gene expression
    12:00Howard Gendelman: HIV-1 Hijacks Tunneling Nanotubes and Secretory Microvesicles for Intercellular Spread in Monocyte-Derived Macrophages
    12:10Lunch

    Session 4 Pathogenesis
    Chairman: Olivier Schwartz, Institut Pasteur, Paris, France

    13:10Biochemical and Virological Analysis of the Preference for the K65R Multi-Resistance Nucleoside Mutation in Subtype C Viruses
    Mark Wainberg, McGill University, Montreal, Canada
    13:20Post-entry events of efficient R5 vs. inefficient X4 HIV-1 replication in primary CD4+ T lymphocytes, a transcriptome analysis
    Guido Poli, San Raffaele Scientific Institute, Milan, Italy
    13:40Retroviral envelope and their receptors: on the (nutrient) road again
    Marc Sitbon, Institut de Genetique Moleculaire de Montpellier, Montpellier, France
    14:00Endogenous Retroelements and Autoimmunity
    Dan Stetson, University of Washington, Seattle, USA
    14:20Role of Regulatory T cells in the pathogenesis of HIV-1 infection
    Yves Levy, Groupe Henri-Mondor Albert-Chenevier, Creteil, France
    14:40Coffee Break
    15:10Inflammatory control in AIDS-resistant non human primates
    Michaela Müller-Trutwin, Institut Pasteur, Paris, France

    Selected Talks

    15:30Fabrizio Mammano: Partial inhibition of HIV replication by type-I interferons: impact of cell-to-cell viral transfer
    15:40Prabal Banerjee: HTLV-1 infection of humanized SCID mice recapitulates Adult T-cell Leukemia/Lymphoma (ATLL) development
    15:50Mickaël J. Ploquin: High avidity virus-specific CD4+ T cells are lost during retroviral infection upon cognate interaction with B cells
    16:00Pierre Roques: Tissue viral dynamics in SIV infected macaques with highly active antiviral therapy (HAART)
    16:10Julien Guergnon: What do we learn from genome wide association study performed on HIV-1 infected Long Term Non Progressors individuals?

    Closing Conference

    16:20Novel vaccine and gene therapy approaches against HIV-AIDS
    Ben Berkhout, University of Amsterdam, Amsterdam, Netherlands
    16:40Closing Address
    Monsef Benkirane, Institut de Genetique Humaine, Montpellier, France
    17:00End of day 3
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